| 1 | Power Team Messina | Inferrera Sabrina, Palella Germana, Grifo' Gabriele, Sidoti Riccardo | 02'09''41 | |  |  | |
50m 34.24 (34.24) 100m 40.07 (05.83) [40.07] 150m 1:14.31 (34.24) 200m 1:40.60 (26.29) [1:00.53] 250m 2:09.41 (28.81) |
| 2 | Ulysse - Messina | Dibilio Simone, Cannizzaro Alessia, Battaglia Antonio, Pandolfino Daniela | 02'11''77 | | | | |
50m 35.55 (35.55) 100m 36.36 (00.81) [36.36] 150m 1:11.91 (35.55) 200m 1:38.84 (26.93) [1:02.48] 250m 2:11.77 (32.93) |
| 3 | Eidos ASD - Canicatti' | Marche Sofia, Russello Paolo, Ficili Sofia Maria Pia, D'Agostino Andrea | 02'12''20 | | | | |
50m 37.98 (37.98) 100m 39.12 (01.14) [39.12] 150m 1:17.10 (37.98) 200m 1:46.27 (29.17) [1:07.15] 250m 2:12.20 (25.93) |
| 4 | Altair Nuoto SSD - Catania | Interlandi Angelo Francesco, Quattrocchi Gloria, Azzarelli Gaspare, Siciliano Sofia | 02'12''30 | | | | |
50m 34.50 (34.50) 100m 35.62 (01.12) [35.62] 150m 1:10.12 (34.50) 200m 1:37.10 (26.98) [1:01.48] 250m 2:12.30 (35.20) |
| 5 | Brizz Nuoto - Acireale | Guerrera Elena, Maggiulli Enrico Edoardo Maria, Miceli Paola, Spina Mauro | 02'13''05 | | | | |
50m 34.85 (34.85) 100m 35.53 (00.68) [35.53] 150m 1:10.38 (34.85) 200m 1:47.47 (37.09) [1:11.94] 250m 2:13.05 (25.58) |
| 6 | Nuoto Milazzo ASD | Tumeo Ludovica, Sottile Roberto, Laquidara Riccardo Andrea, Cautela Gaia | 02'14''17 | | | | |
50m 37.32 (37.32) 100m 38.37 (01.05) [38.37] 150m 1:15.69 (37.32) 200m 1:44.97 (29.28) [1:06.60] 250m 2:14.17 (29.20) |
| 7 | Altair Nuoto SSD - Catania | Crocetta Federica, Massimino Giulio, Costa Simone, Fragapane Roberta | 02'15''96 | | | | |
50m 33.55 (33.55) 100m 36.03 (02.48) [36.03] 150m 1:09.58 (33.55) 200m 1:44.76 (35.18) [1:08.73] 250m 2:15.96 (31.20) |
| 8 | Ondablu Ragusa ASD | Occhipinti Flavio Giuseppe, Noto Alessia, Nativo Mariaelena, Assenza Simone | 02'16''85 | | | | |
50m 35.83 (35.83) 100m 38.47 (02.64) [38.47] 150m 1:14.30 (35.83) 200m 1:46.21 (31.91) [1:07.74] 250m 2:16.85 (30.64) |
| 9 | Polisportiva Sport Club Erea ASD | Iurato Lucrezia, Giampiccolo Salvatore, Guastella Gianmarco, Milone Arianna | 02'18''68 | | | | |
50m 37.14 (37.14) 100m 1:14.12 (36.98) [1:14.12] 150m 1:48.01 (33.89) 200m 2:18.68 (30.67) [1:04.56] |
| 10 | Tennis Club Match Ball ASD - Siracusa | Motta Tommaso, Moscuzza Martina, Zappala' Lucia Rachele, Andolina Alessandro | 02'19''36 | | | | |
50m 40.20 (40.20) 100m 41.77 (01.57) [41.77] 150m 1:21.97 (40.20) 200m 1:53.14 (31.17) [1:11.37] 250m 2:19.36 (26.22) |
| 11 | Island ASD - Milazzo | Cicciari Salvatore, Di Natale Aurora, Minolfi Francesca, Dauccia Mattia | 02'22''25 | | | | |
50m 33.77 (33.77) 100m 39.94 (06.17) [39.94] 150m 1:13.71 (33.77) 200m 1:51.95 (38.24) [1:12.01] 250m 2:22.25 (30.30) |
| 12 | Eidos ASD - Canicatti' | Livatino Maria Rita Gaia, Incardona Carmen Rosa, Locurto Ferdinando, Mantione Giuseppe | 02'23''66 | | | | |
50m 33.82 (33.82) 100m 47.77 (13.95) [47.77] 150m 1:21.59 (33.82) 200m 1:56.17 (34.58) [1:08.40] 250m 2:23.66 (27.49) |
| 13 | Island ASD - Milazzo | Di Pasquale Martino, Italiano Samuele, Mandanici Rossana, Iannello Sarah | 02'23''89 | | | | |
50m 37.78 (37.78) 100m 38.93 (01.15) [38.93] 150m 1:16.71 (37.78) 200m 1:52.92 (36.21) [1:13.99] 250m 2:23.89 (30.97) |
| | Nuoto Milazzo ASD | Buccheri Barbara Cettina Pia, Sottile Chiara, La Greca Riccardo, Buccheri Giuseppe Rosario | Squalificato | |
